表觀遺傳學 國際研討會

Registration 報到註冊

Opening Remarks 開幕典禮

陳俊安 / 台灣表觀遺傳學會理事長

腦激盪短講 I

Session 1: Histone Modifications and Chromatin Architecture

主持人：高承福 / 中央研究院

1. 13:45–13:55
   COUP-TF2 drives ALT development and telomere instability陳律佑 / 中央研究院
2. 13:55–14:05
   Epigenetic Regulation of KDM4A in Viral Oncogenesis張佩靖 / 國立陽明交通大學
3. 14:05–14:15
   Safeguarding the Mitochondrial Genome: Single-Molecule Insights into DNA Unwinding and End Processing by TWINKLE, mtSSB, and MGME1范秀芳 / 國立中山大學
4. 14:15–14:25
   Cross-species Analysis of 3D Genome Architecture During Epithelial-Mesenchymal Transition Reveals Dynamic Chromatin Loop Remodeling黃韻如 / 國立臺灣大學
5. 14:25–14:35
   Functional mapping of Polycomb Repressive Complex 2 uncovers allosteric regulation at the EZH2-SUZ12 interface郭惠思 / 中央研究院
6. 14:35–14:45
   Investigating Mechanobiology in 3D林耿慧 / 中央研究院

贊助廠商技術新品發表

1. 15:40–15:50
   源點生物科技股份有限公司
2. 15:50–16:00
   亞洲準譯股份有限公司
3. 16:00–16:10
   新學社科技有限公司

腦激盪短講 II

Session 2: Nucleic Acid Modifications: DNA Methylation and Epitranscriptomics

主持人：鍾邦柱 / 中國醫藥大學

1. 16:10–16:20
   KDM4C Connects Epigenetic Regulation to Heme Metabolism in Cancer王雯靜 / 國立清華大學
2. 16:20–16:30
   Crosstalk Between Epigenomes and Lipid Production in Arabidopsis Revealed by Pathway Perturbations陳柏仰 / 中央研究院
3. 16:30–16:40
   Beyond RNA Sequence: Structural Signatures for m⁵C Deposition吳權娟 / 國立成功大學
4. 16:40–16:50
   Epitranscriptomic m⁵C Modification in Cancer and Cancer-Driven Skeletal Muscle Wasting in Mice黃柏憲 / 國立成功大學
5. 16:50–17:00
   Decoding Human Disease through Computational Epigenomics徐翡曼 / 國立臺灣大學
6. 17:00–17:10
   Native epitranscriptome sequencing reveals Hepatitis B virus RNA stability and poly(A) tails protected by heavy m6A modification蔡松智 / 中央研究院

腦激盪短講 III

Session 3: Epigenetics in Development, Aging, and Inheritance

主持人：郭紘志 / 中央研究院

1. 09:35–09:45
   Single-locus driven uniform sgRNA expression boosts signal-to-noise ratio and reproducibility of CRISPR perturbation screening of epigenetic factors in organoids林照博 / 上海科技大學
2. 09:45–09:55
   Reversible Tyrosine Phosphorylation Regulates Nuclear Envelope Dynamics陳光超 / 中央研究院
3. 09:55–10:05
   Why Modify the Very Beginning of a Protein and Who Reads the Code? N-Terminal-a-Acetylation, H4R3 Arginine Methylation, and Cell Identity阮麗蓉 / 中央研究院
4. 10:05–10:15
   Role of DNA 6mA methylation in heat-shock response and transgenerational longevity regulation in C. elegans許翱麟 / 國立陽明交通大學
5. 10:15–10:25
   Beyond Lifespan: Sex-Specific Mechanisms of Healthy Aging Revealed by Corylin陳金銓 / 長庚大學

腦激盪短講 IV

Session 4: Regulatory RNAs and Chromatin Crosstalk

主持人：林劭品 / 台灣大學

1. 10:40–10:50
   Uncovering R-loop Regulation of Genome Organization in BRCA1-Deficient Cancers吳敦仁 / 中央研究院
2. 10:50–11:00
   Targeting LncRNA Myca Restores MYC Degradation and Suppresses Tumor Progression李育儒 / 中央研究院
3. 11:00–11:10
   RNA-Guided Chromatin Remodeling: Hypoxia-Induced lncRNA MAHAC Scaffolds an H4K5ac Chromatin-Modifying Complex to Promote Epithelial-Mesenchymal Transition許凱文 / 中國醫藥大學
4. 11:10–11:20
   Coding circSDHAF2 reprograms lipid metabolism in cancer蕭貴陽 / 國立中興大學
5. 11:20–11:30
   TERRA links telomere dysfunction, oxidative stress, and inflammation during aging朱雪萍 / 國立臺灣大學
6. 11:30–11:40
   Beyond Transcription: RNA Regulatory Networks Governing Human Cardiomyocyte Maturation蔡素宜 / 國立臺灣大學
7. 11:40–11:50
   A Novel lncRNA-Mediated Regulatory Axis of Lysine-Specific Demethylase 1 Controls Germline Stem Cell Differentiation during Drosophila Oogenesis李敏嘉 / 國立陽明交通大學
8. 11:50–12:00
   The Multifunctional RNA-Binding Protein KSRP Orchestrates Gene Regulatory Networks in Cancer楊奕婕 / 臺北醫學大學

腦激盪短講 V

Session 5: Metabolic Epigenetics and Immunology

主持人：吳國瑞 / 林口長庚醫院

1. 14:45–14:55
   Targeting USP24 inhibits drug resistance acquired from cancer therapy洪建中 / 國立成功大學
2. 14:55–15:05
   Alternative Splicing of Interleukin-33: A Driver of Cytosolic Localization and Oncogenic Functions王憶卿 / 國立成功大學
3. 15:05–15:15
   Epigenetic Regulation of Metabolic Programming by Early-Life Ketone Signaling林甫容 / 國立臺灣大學
4. 15:15–15:25
   Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations楊皇煜 / 長庚大學

腦激盪短講 VI

Session 6: Cancer Epigenomics and Translational Therapeutics

主持人：王憶卿 / 國立成功大學

1. 15:40–15:50
   HURP: A Microtubule Stabilizer, Drug Resistance Factor, and Tubulin Code Writer夏國強 / 中央研究院
2. 15:50–16:00
   Navigating EGFR Inhibitor Resistance: Target Discovery and Novel Therapeutic Strategies in Lung Cancer李培志 / 中國醫藥大學醫學院
3. 16:00–16:10
   Immune Reprogramming of Tumor-associated T Cell Subsets with Clinical Implications in Lung Cancer郭懿瑩 / 高雄醫學大學
4. 16:10–16:20
   Targeted Protein Dephosphorylation: Bridging Pathological Signaling to Epigenetic Control陳伯翰 / 國立成功大學
5. 16:20–16:30
   Restoring Protein Function by Antisense Oligonucleotide-Mediated Reprogramming of Co-translational Protein Folding余建泓 / 國立成功大學
6. 16:30–16:40
   Epigenetic Control of Hippo-YAP Signaling in Liver Regeneration and Cancer袁維謙 / 國立陽明交通大學